Grant agreement ID:101060211
Funded under: HORIZON-CL6-2021-ZEROPOLLUTION-01-10
BIOSYSMO is a 48-month action that will develop a computationally-assisted framework for designing and optimizing synergistic biosystems combining the required pathways and traits to achieve the most efficient degradation and sequestration of pollutant mixtures.
These biosystems will comprise combinations of bacteria, fungi and plants containing the natural or engineered pathways required for pollutants degradation and identified based on a computationally-assisted analysis. BIOSYSMO will take advantage of the high natural microbial diversity by screening samples from polluted sites and locations affected by diffuse pollution to identify natural microorganisms already present and able to metabolize the target pollutants. The search will be expanded to microorganisms previously identified and characterized by applying data mining tools to genomic and metagenomic data available in public repositories.
The construction and optimization of synergistic biosystems will combine approaches based on 1) enhancing plant-microbe (bacteria, fungi) interactions to achieving combinations with improved pollutant uptake and/or degradation; 2) engineering bacteria, for improved degradation and bioaugmentation, and plants (poplar tree), for improved microbial colonization and pollutant uptake; 3) constructing artificial micro-structured consortia into aggregates and biofilms, containing all the required pathways for pollutant removal; and 4) applying bioelectrochemical systems (BES) as stand-alone or in hybrid systems. The different key players will be identified and combined to formulate innovative biosystems with the assistance of genome-scale metabolic (GEM) models for elucidating and simulating the key metabolic pathways. The constructed biosystems will be applied in conventional (phytoremediation, biopile, bioaugmentation) and innovative (BES, hybrid BES-phytoremediation) bioremediation approaches optimized for the treatment of mixtures of pollutants in soil, sediments and water.
The Project consortium consists of 12 partners across Europe, putting effort together towards the formulation and application of a computational model-driven framework for the design and improvement of synergetic biosystems for removal of mixed contaminants from polluted soils, sediments and (ground)water.